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Genomics|Features|COPD

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease: Public Health and Genomic Insights - March 30, 2015

CDC and Related Info

• The burden of COPD
• Understanding the rise in medical costs for people with COPD
• Chronic Obstructive Pulmonary Disease (COPD)
• Genes reported in relation to COPD risk, including genomewide association studies via theHuGE Navigator

CDC information: The burden of COPD

Epigenetic mechanisms in chronic obstructive pulmonary disease.
Zong DD et al. Eur Rev Med Pharmacol Sci 2015 Mar (5) 844-56

Vitamin D-binding protein gene polymorphisms and chronic obstructive pulmonary disease susceptibility: A meta-analysis.
Xie X et al. Biomed Rep 2015 Mar (2) 183-188

Diagnosing α1-antitrypsin deficiency: how to improve the current algorithm.
McElvaney NG et al. Eur Respir Rev 2015 Mar (135) 52-57

Targeted screening programmes in COPD: how to identify individuals with α1-antitrypsin deficiency.
Chorostowska-Wynimko J et al. Eur Respir Rev 2015 Mar (135) 40-45

Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods.
Morrow JD et al. BMC Med Genomics 2015 Jan 13. (1) 1

Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.
Yoo S et al. PLoS Genet. 2015 Jan (1) e1004898

Genome Wide Association Study Identifies Novel Loci Associated with Airway Responsiveness in COPD.
Hansel NN et al. Am. J. Respir. Cell Mol. Biol. 2014 Dec 16.

Vitamin D binding protein genotype variants and risk of chronic obstructive pulmonary disease: a meta-analysis.
Horita N et al. Respirology 2015 Feb (2) 219-25

The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research.
Cano I et al. J Transl Med 2014 Nov 28. S6

Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.
Castaldi PJ et al. Hum. Mol. Genet. 2015 Feb 15. (4) 1200-10

Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
Lee JH et al. Respir. Res. 2014 (1) 113

Chronic Obstructive Pulmonary Disease: Genetics and Public Health - August 7, 2014

CDC information: Understanding the rise in medical costs for people with COPD

CDC information: COPD is a group of diseases that cause airflow blockage. It includes emphysema, chronic bronchitis, and in some cases asthma. Risk factors include tobacco, pollution and genetic factors

Alpha-1 antitrypsin deficiency is most common genetic condition associated with emphysema

Find out about COPD Genetics from the COPDGene Genetic Epidemiology Study

Did you know? There are >600 genes reported in relation to COPD risk and outcomes including 27 genomewide association studies. To find out more visit the HuGE Navigator

Check out genetic conditions and tests associated with COPD from the NIH Genetic Testing Registry