Genetics of Skin Cancer (PDQ®)–Health Professional Version
SECTIONS
- Introduction
- Basal Cell Carcinoma
- Squamous Cell Carcinoma
- Melanoma
- Rare Skin Cancer Syndromes
- Psychosocial Issues in Familial Melanoma
- Changes to This Summary (06/30/2016)
- About This PDQ Summary
- View All Sections
Changes to This Summary (06/30/2016)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that a study on the heritability of cancer among 80,309 monozygotic and 123,382 dizygotic twins showed that nonmelanoma skin cancers (NMSCs) have a heritability of 43%, suggesting that almost half of the risk of NMSC is caused by inherited factors; additionally, the cumulative risk of NMSC was 1.9-fold higher for monozygotic than for dizygotic twins (cited Mucci et al. as reference 4).
Revised text to state that Rombo syndrome, a very rare probably autosomal dominant genetic disorder associated with basal cell carcinoma, has been outlined in three case series in the literature. Also added text to state that the genetic basis of Rombo syndrome is not known.
Added text to state that a study on the heritability of cancer among 80,309 monozygotic and 123,382 dizygotic twins showed that NMSCs have a heritability of 43%, suggesting that almost half of the risk of NMSC is caused by inherited factors; additionally, the cumulative risk of NMSC was 1.9-fold higher for monozygotic than for dizygotic twins (cited Mucci et al. as reference 60).
Added text to state that a study on the heritability of cancer among 80,309 monozygotic and 123,382 dizygotic twins showed that melanoma has a heritability of 58%, suggesting that more than half of the risk of melanoma is caused by inherited factors (cited Mucci et al. as reference 67).
This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.
.png)
No hay comentarios:
Publicar un comentario