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Genomics|Features|Schizophrenia

Schizophrenia: Recent Genomic Insights - April 6, 2015

CDC and Related Info

• Burden of mental illness
• Genes reported in relation to schizophrenia, including genomewide association studies via theHuGE Navigator

Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: A Danish population-based study and meta-analysis.
Agerbo E et al. JAMA Psychiatry 2015 Apr 1.

Early onset schizophrenia: Gender analysis of genome-wide potential methylation.
Ali BF et al. Clin. Chim. Acta 2015 Mar 31.

The importance of endophenotypes in schizophrenia research.
Braff DL et al. Schizophr. Res. 2015 Apr (1-3) 1-8

Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation.
Avramopoulos D et al. PLoS ONE 2015 (3) e0116696

Genome-wide gene pathway analysis of psychotic illness symptom dimensions based on a new schizophrenia-specific model of the OPCRIT.
Docherty AR et al. Schizophr. Res. 2015 Mar 13.

Evaluating historical candidate genes for schizophrenia.
Farrell MS et al. Mol. Psychiatry 2015 Mar 10.

Factor structure and heritability of endophenotypes in schizophrenia: Findings from the Consortium on the Genetics of Schizophrenia (COGS-1).
Seidman LJ et al. Schizophr. Res. 2015 Apr (1-3) 73-9

New NIMH strategic plan aims to focus, accelerate mental health research, NIH News, Mar 26

The National Institute of Mental Health Strategic Plan

Psychiatric Disorders: New Genomic Insights - January 21, 2015

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Psychiatric Genomics Consortium. Nature Neuroscience, January 19, 2015

The Psychiatric Genomics Consortium conducts mega-analyses of genome-wide genetic data for psychiatric disorders.

Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.
Neale BM, Sklar P. Curr Opin Neurobiol. 2015 Feb;30C:131-138.

Genetic determinants of depression: recent findings and future directions.
Dunn EC, et al. Harv Rev Psychiatry. 2015 Jan-Feb;23(1):1-18

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.
Hess JL, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168(1):14-35

Genetics of complex traits in psychiatry.
Gelernter J. Biol Psychiatry. 2015 Jan 1;77(1):36-42

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.
Doherty JL, Owen MJ. Genome Med. 2014 Apr 28;6(4):29.

Schizophrenia: Recent Genomic Insights - September 18, 2014

CDC information: Burden of mental illness

NIMH · Schizophrenia's genetic "skyline" rising

Exploring the complex genetics of schizophrenia, by Dr. Francis Collins, NIH Director's Blog, Jan 28

Did you Know? >1500 genes have been reported in relation to risk and outcomes of schizophrenia, including >200 genomewide association studies. To find out more, visit the HuGE Navigator

Check out genetic disorders and tests associated with schizophrenia, from the NIH Genetic Testing Registry

SZGene (SchizophreniaGene) Database: Field Synopsis of Genetic Association Studies in SZ

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Javier Arnedo, et al. Am J Psychiatry 2014 Sep 15

Schizophrenia 'made up of eight specific genetic disorders', Medical News Today, Sep 15

Schizophrenia is eight different diseases, not one, by Liz Szabo, USA Today, Sep 15

Schizophrenia subtypes identified by combining genetic, clinical data, Genomeweb Daily, Sep 15

National Society of Genetic Counselors blog post : Is mental illness inherited? How family history and environment impact mental health

The causes of schizophrenia, from the National Alliance on Mental Illness