Schizophrenia: Recent Genomic Insights - April 6, 2015
CDC and Related Info
- Burden of mental illness
- Genes reported in relation to schizophrenia, including genomewide association studies via theHuGE Navigator
Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: A Danish population-based study and meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Agerbo E et al. JAMA Psychiatry 2015 Apr 1.
Agerbo E et al. JAMA Psychiatry 2015 Apr 1.
Early onset schizophrenia: Gender analysis of genome-wide potential methylation.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Ali BF et al. Clin. Chim. Acta 2015 Mar 31.
Ali BF et al. Clin. Chim. Acta 2015 Mar 31.
The importance of endophenotypes in schizophrenia research.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Braff DL et al. Schizophr. Res. 2015 Apr (1-3) 1-8
Braff DL et al. Schizophr. Res. 2015 Apr (1-3) 1-8
Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Avramopoulos D et al. PLoS ONE 2015 (3) e0116696
Avramopoulos D et al. PLoS ONE 2015 (3) e0116696
Genome-wide gene pathway analysis of psychotic illness symptom dimensions based on a new schizophrenia-specific model of the OPCRIT.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Docherty AR et al. Schizophr. Res. 2015 Mar 13.
Docherty AR et al. Schizophr. Res. 2015 Mar 13.
Evaluating historical candidate genes for schizophrenia.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Farrell MS et al. Mol. Psychiatry 2015 Mar 10.
Farrell MS et al. Mol. Psychiatry 2015 Mar 10.
Factor structure and heritability of endophenotypes in schizophrenia: Findings from the Consortium on the Genetics of Schizophrenia (COGS-1).![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Seidman LJ et al. Schizophr. Res. 2015 Apr (1-3) 73-9
Seidman LJ et al. Schizophr. Res. 2015 Apr (1-3) 73-9
Psychiatric Disorders: New Genomic Insights - January 21, 2015
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.
Psychiatric Genomics Consortium. Nature Neuroscience, January 19, 2015
The Psychiatric Genomics Consortium conducts mega-analyses of genome-wide genetic data for psychiatric disorders.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Neale BM, Sklar P. Curr Opin Neurobiol. 2015 Feb;30C:131-138.
Neale BM, Sklar P. Curr Opin Neurobiol. 2015 Feb;30C:131-138.
Genetic determinants of depression: recent findings and future directions.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Dunn EC, et al. Harv Rev Psychiatry. 2015 Jan-Feb;23(1):1-18
Dunn EC, et al. Harv Rev Psychiatry. 2015 Jan-Feb;23(1):1-18
Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Hess JL, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168(1):14-35
Hess JL, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168(1):14-35
Genetics of complex traits in psychiatry.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Gelernter J. Biol Psychiatry. 2015 Jan 1;77(1):36-42
Gelernter J. Biol Psychiatry. 2015 Jan 1;77(1):36-42
Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Doherty JL, Owen MJ. Genome Med. 2014 Apr 28;6(4):29.
Doherty JL, Owen MJ. Genome Med. 2014 Apr 28;6(4):29.
Schizophrenia: Recent Genomic Insights - September 18, 2014
CDC information: Burden of mental illness
Exploring the complex genetics of schizophrenia,
by Dr. Francis Collins, NIH Director's Blog, Jan 28
Did you Know? >1500 genes have been reported in relation to risk and outcomes of schizophrenia, including >200 genomewide association studies. To find out more, visit the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Check out genetic disorders and tests associated with schizophrenia,
from the NIH Genetic Testing Registry
SZGene (SchizophreniaGene) Database:
Field Synopsis of Genetic Association Studies in SZ
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
Javier Arnedo, et al. Am J Psychiatry 2014 Sep 15
Javier Arnedo, et al. Am J Psychiatry 2014 Sep 15
Schizophrenia 'made up of eight specific genetic disorders',
Medical News Today, Sep 15
Schizophrenia is eight different diseases, not one,
by Liz Szabo, USA Today, Sep 15
Schizophrenia subtypes identified by combining genetic, clinical data,
Genomeweb Daily, Sep 15
National Society of Genetic Counselors blog post : Is mental illness inherited? How family history and environment impact mental health![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tDi6j3k1p9CW3fwK58dJOPh4DhoUIQdEpD6QLKRpbGfeyOoCdYuNJ4Q3hIkmLykwG84cPR6CyxqinRxLL1zVRDPslVF8hxbk6iIx_2XaNoKxQ_Hl9wC8zI=s0-d)
The causes of schizophrenia,
from the National Alliance on Mental Illness
The causes of schizophrenia,
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