Diabetes
Diabetes: Recent Genomic Insights - April 14, 2015
CDC and Related Info
- Prediabetes and risk factors
- Prevent type 2 diabetes
- Will diabetes be part of your story?
- Does diabetes run in your family? Take steps towards better health!
- Check your knowledge: diabetes and pregnancy
- Diabetes Latest
- Prediabetes: Am I at risk?
- Living with diabetes: Keep your feet healthy
- Genes reported in relation to diabetes, including genomewide association studies via theHuGE Navigator
Screening for type 2 diabetes mellitus: A systematic review for the U.S. Preventive Services Task Force 
Selph S et al. Annals of Internal Medicine, April 14, 2015
Selph S et al. Annals of Internal Medicine, April 14, 2015
Screening for hyperglycemia: The gateway to diabetes prevention and management for all Americans
Venkat Narayan et al. Annals of Internal Medicine, April 14, 2015
Venkat Narayan et al. Annals of Internal Medicine, April 14, 2015
Understanding type 2 diabetes: from genetics to epigenetics.
Raciti GA et al. Acta Diabetol 2015 Apr 5.
Raciti GA et al. Acta Diabetol 2015 Apr 5.
The genetics of diabetic complications.
Ahlqvist E et al. Nat Rev Nephrol 2015 Mar 31.
Ahlqvist E et al. Nat Rev Nephrol 2015 Mar 31.
Patient beliefs and behaviors about genomic risk for type 2 diabetes: implications for prevention.
Gallagher P et al. J Health Commun 2015 Apr 6. 1-8
Gallagher P et al. J Health Commun 2015 Apr 6. 1-8
Genetics of type 2 diabetes-pitfalls and possibilities.
Prasad RB et al. Genes (Basel) 2015 (1) 87-123
Prasad RB et al. Genes (Basel) 2015 (1) 87-123
Hispanic Americans living in the United States and their risk for obesity, diabetes and kidney disease: Genetic and environmental considerations.
Yracheta JM et al. Postgrad Med 2015 Mar 7. 1-8
Yracheta JM et al. Postgrad Med 2015 Mar 7. 1-8
Metabolomics and diabetes: analytical and computational approaches.
Sas KM et al. Diabetes 2015 Mar (3) 718-32
Sas KM et al. Diabetes 2015 Mar (3) 718-32
Integrated genomic and BMI analysis for type 2 diabetes risk assessment.
Lebrón-Aldea D et al. Front Genet 2015 75
Lebrón-Aldea D et al. Front Genet 2015 75
The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for Type 2 diabetes.
Walford GA et al. PLoS ONE 2015 (3) e0121553
Walford GA et al. PLoS ONE 2015 (3) e0121553
The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes.
Harder MN et al. PLoS ONE 2015 (3) e0120890
Harder MN et al. PLoS ONE 2015 (3) e0120890
Prediabetes: Public Health and Genomic Insights - March 12, 2015
Are you screening for prediabetes? Prevent diabetes STAT, tool kit from the American Medical Association and the Centers for Disease Control and Prevention
tool kit from the American Medical Association and the Centers for Disease Control and Prevention
Download Prevent Diabetes STAT tool kit
Screen, Test, Act, Today
Screen, Test, Act, Today
CDC information: Prediabetes and risk factors
Risk factors include family health history
Risk factors include family health history
Risk assessment tools for detecting those with pre-diabetes: a systematic review.
Barber SR et al. Diabetes Res. Clin. Pract. 2014 Jul (1) 1-13
Barber SR et al. Diabetes Res. Clin. Pract. 2014 Jul (1) 1-13
The personalized approach for detecting prediabetes and diabetes.
Dankner R et al. Curr Diabetes Rev 2015 Jan 9.
Dankner R et al. Curr Diabetes Rev 2015 Jan 9.
Family awareness. Monitoring diabetes risk.
Hieronymus L et al. Diabetes Self Manag 2014 Jul-Aug (4) 22-4, 26
Hieronymus L et al. Diabetes Self Manag 2014 Jul-Aug (4) 22-4, 26
Find out which genes have been reported in relation to prediabetes, from the HuGE Navigator
from the HuGE NavigatorPrevent Type 2 Diabetes: Insights from Family History and Genomics - February 9, 2015
Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.
Johansen Taber KA, et al. Appl Clin Genet. 2015 Jan 7;8:1-8.
Johansen Taber KA, et al. Appl Clin Genet. 2015 Jan 7;8:1-8.
Rare and common genetic events in type 2 diabetes: What should biologists know?
Bonnefond A, et al. Cell Metab. 2015 Jan 27. pii:
Bonnefond A, et al. Cell Metab. 2015 Jan 27. pii:
Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.
Berná G, et al. Nutrients. 2014 Nov 21;6(11):5338-69
Berná G, et al. Nutrients. 2014 Nov 21;6(11):5338-69
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Wessel J. et al. Nat Commun. 2015 Jan 29;6:5897
Wessel J. et al. Nat Commun. 2015 Jan 29;6:5897
Type 2 Diabetes: Family History and Genetics - November 13, 2014
CDC feature: Will diabetes be part of your story? Know your risk for diabetes and see if it could be a part of your story
National Diabetes Education Program Video: Preventing Type 2 Diabetes: Maintaining a healthy weight. Losing weight wasn't easy for Latecia, but after seeing her mom live with diabetes, she knew she needed to make changes in her life to prevent the disease
Preventing Type 2 Diabetes: Maintaining a healthy weight. Losing weight wasn't easy for Latecia, but after seeing her mom live with diabetes, she knew she needed to make changes in her life to prevent the disease
Recent Insights
Susceptibility to type 2 diabetes mellitus—from genes to prevention.
Marie-France Hivert et al. Nature Reviews Endocrinology 2014;10:198-205
Marie-France Hivert et al. Nature Reviews Endocrinology 2014;10:198-205
Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.
Basile KJ, et al. Curr Diab Rep. 2014 Nov;14(11):550.
Basile KJ, et al. Curr Diab Rep. 2014 Nov;14(11):550.
Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes.
Vaag A, et al. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108
Vaag A, et al. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1099-108
Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus.
Banerjee M, et al. World J Diabetes. 2014 Aug 15;5(4):493-504.
Banerjee M, et al. World J Diabetes. 2014 Aug 15;5(4):493-504.
Metformin pharmacogenomics: current status and future directions.
Pawlyk AC, et al. Diabetes. 2014 Aug;63(8):2590-9.
Pawlyk AC, et al. Diabetes. 2014 Aug;63(8):2590-9.
Diabetes & Pregnancy: Role of Genetics and Family History - November 6, 2014
CDC information: November is Diabetes Awareness Month. How much do you know about diabetes during pregnancy? Check your knowledge
From the National Diabetes Education Program: Family Health History and Diabetes- If you are a woman who had gestational diabetes during pregnancy, you are at increased risk for developing diabetes, and the child of that pregnancy is at increased risk for obesity and type 2 diabetes
- If you are a woman who had gestational diabetes during pregnancy, you are at increased risk for developing diabetes, and the child of that pregnancy is at increased risk for obesity and type 2 diabetes
From Medline & NLM Reference: You are at greater risk for gestational diabetes if you have a family history of diabetes
Did you know? 264 genes have been reported in relation to risk and outcomes of gestational diabetes, including 2 genomewide association studies. To find out more, visit the HuGE Navigator
Recent Insights
Obesity and diabetes: from genetics to epigenetics.
Burgio E, et al. Mol Biol Rep. 2014 Sep 25
Burgio E, et al. Mol Biol Rep. 2014 Sep 25
Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.
Quilter CR, et al. FASEB J. 2014 Nov;28(11):4868-79
Quilter CR, et al. FASEB J. 2014 Nov;28(11):4868-79
Genetic counseling for diabetes mellitus.
Stein SA, et al. Curr Genet Med Rep. 2014 Jun 1;2(2):56-67.
Stein SA, et al. Curr Genet Med Rep. 2014 Jun 1;2(2):56-67.
Diabetes Prevention: Family History and Genetics - September 11, 2014
Recommendation from the Task Force on Community Preventive Services (2014) Diabetes Prevention and Control: Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among People at Increased Risk
Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among People at Increased Risk
CDC information: More than 29 million Americans have diabetes; 1 in 4 doesn't know
If you have a mom, dad, brother or sister with type 2 diabetes you have a greater chance of getting the disease, the National Diabetes Education Program
the National Diabetes Education Program
CDC information: Prediabetes: Am I at risk?
Did you know? More than 3400 genes have been reported with risk of type 2 diabetes and its outcomes, including more than 160 genomewide association studies. To find out more, visit theHuGE Navigator
The fight against type 2 diabetes: The promise of genomics, Sandra Adamson Fryhofer, Medscape podcast, July 11, 2014
Sandra Adamson Fryhofer, Medscape podcast, July 11, 2014
Check out genetic disorders and tests associated with diabetes at the NIH Genetic Testing Registry
Diabetes Complications: Role of Genomics - May 8, 2014
The global diabetes epidemic "A perfect storm of commerce, lifestyle and genetics", by Kasia Lipska, New York Times, Apr 25
"A perfect storm of commerce, lifestyle and genetics", by Kasia Lipska, New York Times, Apr 25
CDC information on diabetes complications: If you have diabetes, it's important to take care of your feet and the rest of your body
The genetics of vascular complications in diabetes mellitus
Dan Farbstein, et al. Cardiol Clin. 2010 Aug;28(3):477-96
Dan Farbstein, et al. Cardiol Clin. 2010 Aug;28(3):477-96
Mechanisms of diabetic complications
Forbes JM. Physiol Rev (2013)
Forbes JM. Physiol Rev (2013)
Metabolic memory and chronic diabetes complications: Potential role for epigenetic mechanisms
Robert V. Inti et al. Current Diabetes Rep (2013)
Robert V. Inti et al. Current Diabetes Rep (2013)
Did you know? More than 3300 genes have been reported in relation to risk of type 2 diabetes and its complications? For additional information, visit the HuGE Navigator
Did you know? 19 genomewide association studies have reported on genetic risk in relation to diabetes complications? Find out more from the HuGE Navigator
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