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Genomics|Features|HIV/AIDS

HIV/AIDS

HIV/AIDS: Recent Genomic Insights - December 4, 2014

CDC information on World AIDS Day

CDC Vital Signs: HIV care saves lives. Viral suppression is key, November 2014

Recent Advances

Review: influence of ART on HIV genetics. 
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Hu W, et al.  PNAS, Jul 21, 2014.

Genome editing cuts out HIV
Grens K. The Scientist, Jul 21, 2014.

Gene researchers work to engineer HIV-resistant cells 
Hampton T. JAMA, Jul 9, 2014.

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.

Promising results from HIV gene editing therapy, PHG Foundation, Mar 10

Testing for risk and protective trends in genetic analyses of HIV acquisition.
Mccarthy JM, et al. Biostatistics. 2014 Sep 29

Biomarkers of HIV-associated Cancer.
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi

HIV/AIDS Genomics: Advances in Therapy & Tests - July 31, 2014

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Hu W, et al.  PNAS, Jul 21, 2014.

Genome editing cuts out HIV
Grens K. The Scientist, Jul 21, 2014.

Gene researchers work to engineer HIV-resistant cells 
Hampton T. JAMA, Jul 9, 2014.

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.

Promising results from HIV gene editing therapy, PHG Foundation, Mar 10

Check out guidelines on genomic tests associated with HIV/AIDS treatment, from the CDC evidence-based table

HLA-B*5701/abacavir	DHHS Advisory Committee  [PDF 1.46 MB] (2013)  CPIC (2014) FDA-PGx Drug Information (2013)
CCR5-tropic HIV-1 /maraviroc	FDA-PGx Drug Information (2013) HHS Panel  [PDF 1.46 MB] (2013)

Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.

Did you know? 1799 genes have been reported in relation to HIV risk & outcomes including 33 genomewide association studies. To find out more, visit the HuGE Navigator