Amyotrophic Lateral Sclerosis
More on Amyotrophic Lateral Sclerosis - April 1, 2015
CDC and Related Info
- National Amyotrophic Lateral Sclerosis (ALS) Registry
- Amyotrophic Lateral Sclerosis (ALS) Service Locator App
- Amyotrophic Lateral Sclerosis (ALS) Continuing Education Module
- ATSDR ALS Webinar
- National ALS Registry podcast
- ALS e-cards
- The National ALS Registry flickr album
- Genes reported in relation to ALS, including genomewide association studies via theHuGE Navigator
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.
Cirulli ET et al. Science2015 Mar 27. (6229) 1436-1441
Cirulli ET et al. Science2015 Mar 27. (6229) 1436-1441
Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS.
Steinberg KM et al. Sci Rep 2015 9124
Steinberg KM et al. Sci Rep 2015 9124
Network analyses reveal novel aspects of ALS pathogenesis.
Sanhueza M et al. PLoS Genet. 2015 Mar (3) e1005107
Sanhueza M et al. PLoS Genet. 2015 Mar (3) e1005107
Psychiatric genetics, neurogenetics, and neurodegeneration.
Kerner B et al. Front Genet 2014 467
Kerner B et al. Front Genet 2014 467
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Sun S et al. Nat Commun 2015 6171
Sun S et al. Nat Commun 2015 6171
Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci.
McLaughlin RL et al. Genomics 2015 Apr (4) 237-41
McLaughlin RL et al. Genomics 2015 Apr (4) 237-41
Amyotrophic Lateral Sclerosis: Genomic Insights - February 23, 2015
SnapShot: Genetics of ALS and FTD.
Guerreiro Rita et al. Cell 2015 Feb 12. (4) 798-798.e1
Guerreiro Rita et al. Cell 2015 Feb 12. (4) 798-798.e1
The distinct genetic pattern of ALS in Turkey and novel mutations.
Özoguz Aslihan et al. Neurobiol. Aging 2015 Jan 10.
Özoguz Aslihan et al. Neurobiol. Aging 2015 Jan 10.
Therapeutic development in amyotrophic lateral sclerosis.
Bucchia Monica et al. Clin Ther 2015 Feb 6.
Bucchia Monica et al. Clin Ther 2015 Feb 6.
MicroRNAs: Newcomers into the ALS Picture.
Volonté C et al. CNS Neurol Disord Drug Targets 2015 Jan 16.
Volonté C et al. CNS Neurol Disord Drug Targets 2015 Jan 16.
Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis.
Morgan Sarah et al. Neurobiol. Aging 2014 Dec 20.
Morgan Sarah et al. Neurobiol. Aging 2014 Dec 20.
Genetic analysis of amyotrophic lateral sclerosis in the Slovenian population.
Vrabec Katarina et al. Neurobiol. Aging 2014 Dec 18.
Vrabec Katarina et al. Neurobiol. Aging 2014 Dec 18.
Application of next-generation sequencing technologies in neurology.
Jiang Teng et al. Ann Transl Med 2014 Dec (12) 125
Jiang Teng et al. Ann Transl Med 2014 Dec (12) 125
Genome-wide association studies in neurology.
Tan Meng-Shan et al. Ann Transl Med 2014 Dec (12) 124
Tan Meng-Shan et al. Ann Transl Med 2014 Dec (12) 124
A second-generation Irish genome-wide association study for amyotrophic lateral sclerosis.
McLaughlin Russell L et al. Neurobiol. Aging 2015 Feb (2) 1221.e7-1221.e13
McLaughlin Russell L et al. Neurobiol. Aging 2015 Feb (2) 1221.e7-1221.e13
Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.
Cady Janet et al. Ann. Neurol. 2015 Jan (1) 100-13
Cady Janet et al. Ann. Neurol. 2015 Jan (1) 100-13
Amyotrophic lateral sclerosis genetic studies: From genome-wide association mapping to genome sequencing.
He Ji et al. Neuroscientist 2014 Nov 5.
He Ji et al. Neuroscientist 2014 Nov 5.
Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.
Smith Bradley N et al. Neuron 2014 Oct 22. (2) 324-31
Smith Bradley N et al. Neuron 2014 Oct 22. (2) 324-31
Amyotrophic Lateral Sclerosis: National Registry, Biorepository and Genetics - August 7, 2014
Prevalence of amyotrophic lateral sclerosis — United States, 2010–2011, 
[PDF 575.05 KB]Agency for Toxic Substances and Disease Registry, MMWR, July 25, 2014
[PDF 575.05 KB]Agency for Toxic Substances and Disease Registry, MMWR, July 25, 2014
National Amyotrophic Lateral Sclerosis (ALS) registry from the Agency for Toxic Substances and Disease Registry
What causes ALS? Although no cause has been found for most cases of ALS, a number of inherited factors have been found to cause familial ALS
National ALS Biorepository. Little is known about the role genetics play in ALS. In order to find out more, researchers need biological samples like blood or tissue from persons living with ALS . ATSDR is coordinating a feasibility study to find the best way to collect and store these samples.
Genetics and ALS: Find out more information from the NIH Genetics Home Reference- An estimated 5 to 10 percent of ALS is familial and caused by mutations in one of several genes
- An estimated 5 to 10 percent of ALS is familial and caused by mutations in one of several genes
Keeping up with genetic discoveries in amyotrophic lateral sclerosis: ALSGene database
Amyotroph Lateral Scler. 2011 Jul;12(4):238-49.
Amyotroph Lateral Scler. 2011 Jul;12(4):238-49.
Did you know there are 194 genes reported in relation to risk and complications of ALS, including 36 genomewide association studies? To find out more, visit the HuGE Navigator
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