Antimicrobial Resistance
Antimicrobial Resistance: Public Health & Genomics Efforts - March 31, 2015
CDC Info
- Patients face more lethal infections from CRE
- CDC blog post:Outsmarting antimicrobial-resistant pathogens
- White House announces national strategy for combating antibiotic-resistant bacteria
- Antibiotic Resistance Solutions Initiative
- Antibiotic / Antimicrobial Resistance
- CDCAdvanced Molecular Detective Initiativeincludes a project ongenomic sequencing of Neisseria gonorrhoeae to respond to the urgent threat of antimicrobial-resistant gonorrhea
Our plan to combat and prevent antibiotic-resistant bacteria,
HHS Secretary, White House Blog Post, Mar 27
Obama unveils $1.2B plan to tackle drug-resistant bacteria,
by Sarah Ferris, the Hill, Mar 27
Antibiotic discovery in the age of structural biology - a comprehensive overview with special reference to development of drugs for the treatment of Pseudomonas aeruginosa infection.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Koehnke A et al. In Vivo 2015 03-04 (2) 161-167
Koehnke A et al. In Vivo 2015 03-04 (2) 161-167
Renaissance in antibiotic discovery: Some novel approaches for finding drugs to treat bad bugs.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Gadakh B et al. Curr. Med. Chem. 2015 Mar 19.
Gadakh B et al. Curr. Med. Chem. 2015 Mar 19.
Proteomics as the final step in the functional metagenomics study of antimicrobial resistance.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Fouhy F et al. Front Microbiol 2015 172
Fouhy F et al. Front Microbiol 2015 172
A microbiological revolution meets an ancient disease: Improving the management of tuberculosis with genomics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Wlodarska M et al. Clin. Microbiol. Rev. 2015 Apr (2) 523-539
Wlodarska M et al. Clin. Microbiol. Rev. 2015 Apr (2) 523-539
Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Sanchez-Padilla E et al. N. Engl. J. Med. 2015 Mar 19. (12) 1181-2
Sanchez-Padilla E et al. N. Engl. J. Med. 2015 Mar 19. (12) 1181-2
Comparative whole genome sequencing of community-associated methicillin-resistant staphylococcus aureus sequence type 8 from primary care clinics in a Texas community.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Lee GC et al. Pharmacotherapy 2015 Feb (2) 220-8
Lee GC et al. Pharmacotherapy 2015 Feb (2) 220-8
Population structure and antimicrobial resistance of invasive serotype IV group B Streptococcus, Toronto, Ontario, Canada.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Teatero S et al. Emerging Infect. Dis. 2015 Apr (4) 585-591
Teatero S et al. Emerging Infect. Dis. 2015 Apr (4) 585-591
Investigation of a possible outbreak of carbapenem-resistant Acinetobacter baumannii in Odense, Denmark using PFGE, MLST and whole-genome-based SNPs.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Hammerum AM et al. J. Antimicrob. Chemother. 2015 Mar 19.
Hammerum AM et al. J. Antimicrob. Chemother. 2015 Mar 19.
Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Ezewudo MN et al. PeerJ 2015 e806
Ezewudo MN et al. PeerJ 2015 e806
Carbapenem-Resistant Enterobacteriaceae: Public Health and Genomic Insights - February 23, 2015
CDC Information: Patients face more lethal infections from CRE
Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Temkin Elizabeth et al. Ann. N. Y. Acad. Sci. 2014 Sep 22-42
Temkin Elizabeth et al. Ann. N. Y. Acad. Sci. 2014 Sep 22-42
Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Conlan Sean et al. Sci Transl Med 2014 Sep 17. (254) 254ra126
Conlan Sean et al. Sci Transl Med 2014 Sep 17. (254) 254ra126
Molecular characteristics of carbapenem-resistant gram-negative bacteria in Southern China.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Zheng Fen et al. Microb. Drug Resist. 2014 Dec 3.
Zheng Fen et al. Microb. Drug Resist. 2014 Dec 3.
Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant enterobacteriaceae in Japan.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Kayama Shizuo et al. Antimicrob. Agents Chemother. 2015 Feb (2) 1356-9
Kayama Shizuo et al. Antimicrob. Agents Chemother. 2015 Feb (2) 1356-9
Global dissemination of extensively drug-resistant carbapenemase-producing Enterobacteriaceae: clinical perspectives on detection, treatment and infection control.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Tängdén T et al. J. Intern. Med. 2014 Dec 29.
Tängdén T et al. J. Intern. Med. 2014 Dec 29.
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Deleo Frank R et al. Proc. Natl. Acad. Sci. U.S.A. 2014 Apr 1. (13) 4988-93
Deleo Frank R et al. Proc. Natl. Acad. Sci. U.S.A. 2014 Apr 1. (13) 4988-93
Antibiotic Resistance: Insights From a Pile of Dirt to Resistomes - January 9, 2015
Promising antibiotic discovered in microbial ‘dark matter’. Potential drug kills pathogens such as MRSA — and was discovered by mining 'unculturable' bacteria,
Heidi Ledford, Nature News, Jan 7
From a pile of dirt, hope for a powerful new antibiotic,
by Denise Grad, New York Times, Jan 7
Microbe found in grassy field contains powerful antibiotic,
Science News, Jan 7
Will new antibiotic Teixobactin save us all? Umm, not quite,
Siouxsie Wiles, Infectious Thoughts, Science Blog, Jan 8
Antibiotics: US discovery labelled 'game-changer' for medicine,
by James Gallagher, BBC News, Jan 7
A new antibiotic kills pathogens without detectable resistance![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Losee L. Ling, Nature, January 7, 2015
Losee L. Ling, Nature, January 7, 2015
What is a resistance gene? Ranking risk in resistomes.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
José L. Martínez, et al. Nature Reviews Microbiology, December 15, 2014
José L. Martínez, et al. Nature Reviews Microbiology, December 15, 2014
Fighting Antimicrobial Resistance: Emerging Role for Genomics - November 26, 2014
Using genomics to tackle antimicrobial resistance,
by Laura Blackburn, PHG Foundation, Nov 20
Genomics and the management of antimicrobial resistance: current successes and future challenges,
PHG Foundation, Policy Brief, November 2014
Outsmarting Antimicrobial-Resistant Pathogens: Role of Genomics - October 30, 2014
New CDC blog post: Outsmarting antimicrobial-resistant pathogens, by Marta Gwinn, CDC Office of Public Health Genomics and guest blogger Clifford McDonald, Division of Healthcare Quality Promotion, NCEZID, CDC
Recent insights
Disentangling human tolerance and resistance against HIV
Regoes R, et al. PLoS Biol 2014; 12(9): e1001951.
Regoes R, et al. PLoS Biol 2014; 12(9): e1001951.
A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics
Donia MS, et al. Cell. 2014;158(6):1402-14.
Comment:
Mining the microbiome for medicines: Set a thief...![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
The Economist, Sep 20, 2014.
Donia MS, et al. Cell. 2014;158(6):1402-14.
Comment:
Mining the microbiome for medicines: Set a thief...
The Economist, Sep 20, 2014.
Infection control in the multidrug-resistant era: tending the human microbiome
Tosh PK, McDonald LC. Clin Infect Dis 2012;54(5):707-13.
Tosh PK, McDonald LC. Clin Infect Dis 2012;54(5):707-13.
Association of antibiotics in infancy with early childhood obesity
Bailey LC, et al. JAMA Pediatr, Sep 29, 2014.
Bailey LC, et al. JAMA Pediatr, Sep 29, 2014.
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
Citorik RJ, et al. Nat Biotechnol, Sep 21, 2014.
Comment:
Battling superbugs with gene-editing system![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Trafton A. Phys.Org, Sep 21, 2014.
Citorik RJ, et al. Nat Biotechnol, Sep 21, 2014.
Comment:
Battling superbugs with gene-editing system
Trafton A. Phys.Org, Sep 21, 2014.
Discovery of modulators of HIV-1 infection from the human peptidome![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vOkHr9hY24SDMzkVM2iUOXfIhqzUiqUlvYrAtOFFk0w5uVVJbXYGfx7VBrBflBpn92jbUG7WOCJSMPV2leo-6k7u6JZ0omR8iphwnji-lXPZwAaFf8SAAS=s0-d)
Munch J, et al. Nat Rev Microbiol 2014; 12: 715–722.
Munch J, et al. Nat Rev Microbiol 2014; 12: 715–722.
Antibiotic Resistance: Genomics & Public Health - September 25, 2014
CDC information: White House announces national strategy for combating antibiotic-resistant bacteria
CDC initiative: Detect and protect against antibiotic resistance
NIH blog post: New strategies in battle against antibiotic resistance include expansion of DNA sequencing capacity and collection of those microbial genetic sequences in a centralized National Database of Resistant Pathogens,
by Drs. Anthony S. Fauci and Francis Collins, Sep 18
US vows to combat antibiotic resistance -strategy lauded, but some fear it is lax on agricultural use,
by Sara Reardon, Nature News, Sep 23
New US strategy on antimicrobial resistance launched,
by Dr Philippa Brice, PHG Foundation, Sep 22
How bacterial genomes could help tackle antibiotic resistance,
by Leila Lehushi, PHG Foundation, Aug 10
Podcast Q&A: How genomics can tackle antimicrobial resistance,
from SciDevNet, May 2014
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