PHGKB: LYNCH SYNDROME - NEW INSIGHTS & IMPLEMENTATION || July 14-20, 2016 || Public Health Genomics Knowledge Base (v1.0)

Public Health Genomics Knowledge Base (v1.0)

PHGKB: LYNCH SYNDROME - NEW INSIGHTS & IMPLEMENTATION

Last Updated: Jul 14, 2016

• Genetic Counselors Are Essential in Genetic Testing for Lynch Syndrome, 
  by Georgia Hurst, Cure, July 6, 2016
• Universal Versus Targeted Screening for Lynch Syndrome: Comparing Ascertainment and Costs Based on Clinical Experience.
  Erten Mujde Z et al. Digestive diseases and sciences 2016 Jul
• Classification of genetic variants in genes associated with Lynch syndrome using a clinical history weighting algorithm.
  Morris Brian et al. BMC genetics 2016 17(1) 99
• Lynch Syndrome Testing: A Missed Opportunity in the Era of Precision Medicine.
  Pasche Boris et al. JAMA 2016 Jul 316(1) 38-39
• Successful implementation of Lynch syndrome screening in a safety net institution.
  Kidambi Trilokesh D et al. Journal of community genetics 2016 Jul
• Tumor Screening and DNA Testing in the Diagnosis of Lynch Syndrome.
  Usha Lydia et al. JAMA 2016 Jul 316(1) 93-94
• Adjusting to Frequent Colonoscopies
  Georgia Hurst, Ambry Genetics, July 4, 2016
• High Frequency of KRAS Mutation in Early Onset Colorectal Adenocarcinoma: Implications for Pathogenesis.
  Watson Rao, et al. Human pathology 2016 6
• IGNITE: Implementing Genomics in Practice
  Disease: Multiple Diseases; Type: Education|Tools; State: Multiple States
• Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors with 2 or More Somatic Mutations in Mismatch Repair Genes.
  Cohen Stacey A, et al. Gastroenterology 2016 6
• Counselling framework for moderate-penetrance cancer-susceptibility mutations.
  Tung Nadine et al. Nature reviews. Clinical oncology 2016 Jun
• How Far Do We Go With Genetic Evaluation? Gene, Panel, and Tumor Testing.
  Lynce Filipa et al. American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting 2016 35e72-8
• Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database.
  Møller Pål et al. Gut 2016 Jun
• Prospective Lynch Syndrome Database 
• Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome.
  Moreno-Ortiz Jose Miguel, et al. Gastroenterology research and practice 2016 0 5278024

• CDC Information (4)
• CDC-Authored Pub (9)

• Human (52)
• Pathogen (0)

• Human (287)
• Pathogen (0)

• Human (115)
• Pathogen (0)

• Guidelines (17)
• Tier Table (11)
• Synthesis (27)

• Huamn (80)
• Pathogen (0)

Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB