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Genomics|Features|Alcohol

Alcohol Awareness Month - April 20, 2015

CDC and Related Info

• Alaska public health nurses address alcohol
• The high cost of excessive drinking to states
• Alcohol and public health
• Alcohol deaths
• Frequently asked questions about alcohol and public health
• CDC Vital Signs:Alcohol poisoning deaths. A deadly consequence of binge drinking,January 2015
• CDC paper:Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.BMJ 2014; 349 July 10, 2014
• Scientific articles related to alcohol, including the most commonly studied genes via theHuGE Navigator

CDC information: Alaska public health nurses address alcohol

NIH recognizes Alcohol Awareness Month 2015

CDC information: The high cost of excessive drinking

Common single nucleotide variants underlying drug addiction: more than a decade of research.
Bühler KM et al. Addict Biol 2015 Jan 21.

The 5-HT7 receptor as a potential target for treating drug and alcohol abuse.
Hauser SR et al. Front Neurosci 2014 448

Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
Eriksson CJP et al. Adv. Exp. Med. Biol. 2015 41-58

Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?
Hart AB et al. Addict Biol 2015 Apr 1.

ACN9 and alcohol dependence: Family-based association analysis in multiplex alcohol dependence families.
Hill SY et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2015 Apr (3) 179-87

Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
Salvatore JE et al. Clin Psychol Sci 2015 Mar (2) 189-201

Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA).
Semmler A et al. Alcohol 2015 Mar (2) 97-101

Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence.
Forero DA et al. Drug Alcohol Depend 2015 Apr 1. 259-63

Alcohol and Public Health: Recent Genomic Insights - January 8, 2015

CDC Vital Signs: Alcohol poisoning deaths. A deadly consequence of binge drinking, January 2015

CDC information: Excessive alcohol use, including underage drinking and binge drinking can lead to increased risk of health problems

Beyond hangovers: Understanding alcohol's impact on your health, from the National Institute for Alcohol Abuse and Alcoholism

Genetics and genomics of alcohol sensitivity.
Morozova  etal. Mol Genet Genomics. 2014 Jun;289(3):253-69.

ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings.
Peng GS, et al. Pharmacogenet Genomics. 2014 Dec;24(12):607-17

Alcohol, Genomics and Public Health July 15, 2014

CDC paper: Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
BMJ 2014; 349 July 10, 2014 

Editorial: Alcohol and cardiovascular disease
MM Glymour, BMJ  (July 2014) 

CDC information: Drinking too much can harm your health. One in 10 deaths among working-age adults aged 20–64 years are due to excessive alcohol use

CDC information: Frequently asked questions about alcohol and public health: Individual reactions to alcohol vary, and are influenced by many factors including family history of alcohol problems

Did you know? The HuGE Navigator includes more than 3000 scientific articles on genetic factors associated with alcohol use and adverse health effects, including 80 genomewide association studies. The most commonly studied genes are ALDH2, ADH1B and ADH1C

Alcohol: Alcoholism and Genomics - May 29, 9014

A family history of alcoholism: Are you at risk? From the National Institute of Alcohol Abuse and Alcoholism

CDC information: Alcohol and public health  

Alcoholism risk factors: The risk of alcoholism is higher for people who have a parent or other close relatives who have problems with alcohol, Mayo Clinic

HuGE Navigator: includes more than 2700 scientific articles on genetic factors associated with alcohol use and adverse health effects, including 63 genomewide association studies. The most commonly studied genes are ALDH2 ADH1B and ADH1C

New findings: Genetic risk prediction and neurobiological understanding of alcoholism.
D F Leve et al. Translational Psychiatry, May 2014

Potential predictive genetic test for alcoholism, PHG Foundation, May 22

Researchers promise new genetic test for alcoholism for which they found no scientific evidence,by Cecile Janssens, Huffington Post, Blog May 23