The CDC Guideline on Opioid Prescribing- Rising to the Challenge ► Public Health Genomics Knowledge Base (v1.0)

Public Health Genomics Knowledge Base (v1.0)








Last Updated: Mar 30, 2016

• Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.
  Yang Hsin-Chou, et al. PLoS genetics 2016 3 (3) e1005910
• The CDC Guideline on Opioid Prescribing- Rising to the Challenge
  Y. Olson, JAMA, March, 2016
• Correlation analysis between an IL-6 genetic polymorphism and non-small cell lung cancer prognosis.
  Zhao K, et al. Genetics and molecular research : GMR 2016 0 (1)
• Opioid metabolism and clinical aspects.
  Mercadante Sebastiano et al. European journal of pharmacology 2015 Dec 71-8
• The pharmacogenetics of opioid therapy in the management of postpartum pain: a systematic review.
  Baber Marta et al. Pharmacogenomics 2016 Jan (1) 75-93
• X Chromosome Inactivation in Opioid Addicted Women.
  Vousooghi Nasim, et al. Basic and clinical neuroscience 2015 7 (3) 179-84
• Human Genetic Variability Contributes to Post-operative Morphine Consumption.
  De Gregori Manuela, et al. The journal of pain : official journal of the American Pain Society 2016 2
• ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.
  Chidambaran V, et al. The pharmacogenomics journal 2016 1
• The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid-Dependent Patients on Methadone Maintenance Therapy.
  Zahari Zalina, et al. Pain and therapy 2016 1
• Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.
  Jones Jermaine D, et al. The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions 2015 12
• Presence or Absence of QTc Prolongation in Buprenorphine-Naloxone Among Youth With Opioid Dependence.
  Poole Sabrina A, et al. Journal of addiction medicine 2015 12
• Clinical Implications of Opioid Pharmacogenomics in Patients With Cancer.
  Bell Gillian C, et al. Cancer control : journal of the Moffitt Cancer Center 2015 10 (4) 426-32
• Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery.
  Dimova Violeta, et al. Journal of pain research 2015 0 829-44
• Modeling respiratory depression induced by remifentanil and propofol during sedation and analgesia using a continuous noninvasive measurement of pCO2.
  Hannam Jacqueline A, et al. The Journal of pharmacology and experimental therapeutics 2015 12
• Increases in Drug and Opioid Overdose Deaths — United States, 2000–2014
  MMWR, December 18, 2015
• The Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy.
  Zahari Zalina, et al. Pain and therapy 2015 11
• Association of A118G polymorphism in the ?-opioid receptor gene with smoking behaviors: a meta-analysis.
  Wang Juan, et al. The Journal of toxicological sciences 2015 0 (6) 711-8
• Morphine-induced anti-nociception and reward in "humanized" mice expressing the mu opioid receptor A118G polymorphism.
  Henderson-Redmond Angela N, et al. Brain research bulletin 2015 10
• Mu Opioid Receptor Polymorphism, Early Social Adversity, and Social Traits.
  Carver Charles S, et al. Social neuroscience 2015 11
• Acute pain Factors predictive of post-operative pain and opioid requirement in multimodal analgesia following knee replacement.
  Thomazeau J, et al. European journal of pain (London, England) 2015 10
• Clues to opioid abuse from state prescription drug monitoring programs 
• [M1-OPIOID RECEPTOR AND CATECHOL-O-METILTRANSFERASE GENES POLYMORPHISM EFFECTS ON PERIOPERATIVE PSYCHOLOGICAL CONDITION OF THE PATIENTS AND THE EFFECTIVENESS OF POSTOPERATIVE ANALGESIA WITH OPIOIDS].
  Potapov A L, et al. Anesteziologiia i reanimatologiia 0 0 (3) 48-51
• Influence of UGT2B7, CYP3A4, and OPRM1 Gene Polymorphisms on Transdermal Buprenorphine Pain Control in Patients with Critical Lower Limb Ischemia Awaiting Revascularization.
  Blanco Francisco, et al. Pain practice : the official journal of World Institute of Pain 2015 9
• Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
  Schwantes-An Tae-Hwi, et al. Behavior genetics 2015 9
• Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence.
  Ali M Adam, et al. Psychiatric genetics 2015 9
• Differential Consequences of Tramadol in Overdosing: Dilemma of a Polymorphic Cytochrome P450 2D6-Mediated Substrate.
  Srinivas Nuggehally R, et al. Journal of pain & palliative care pharmacotherapy 2015 9 1-4
• Acute opioid administration induces hypothalamic-pituitary-adrenal activation and is mediated by genetic variation in interleukin (Il)1B.
  Kershaw Stephanie G, et al. Pharmacology, biochemistry, and behavior 2015 9 9-13
• Event-related potentials in performance monitoring are influenced by the endogenous opioid system.
  Pfabigan Daniela M, et al. Neuropsychologia 2015 9 242-252
• Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl.
  Barratt Daniel T, et al. PloS one 2015 0 (9) e0137179
• [Stabilization of remission in patients with opioid dependence with naltrexone implant: a pharmacogenetic approach].
  Krupitski? E M, et al. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 0 0 (4 Vypusk 2 Addiktivnye rasstroistva) 14-23

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Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB