HIV/AIDS
HIV/AIDS: Public Health and Genomic Insights - July 1, 2015
CDC Info
- Prevalence of dagnosed and undiagnosed HIV infection - United States, 2008-2012.
Hall HI et al. MMWR Morb. Mortal. Wkly. Rep.2015 Jun 26. (24) 657-62
- Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999-2011.
Buchacz K et al. J. Antimicrob. Chemother. 2015 May 15.
- Detection of acute HIV-1 infection by RT-LAMP.
Rudolph DL et al. PLoS ONE 2015 (5) e0126609
- CDC information on HIV/AIDS
- CDC Vital Signs:HIV care saves lives. Viral suppression is key,November 2014
Prevalence of dagnosed and undiagnosed HIV infection - United States, 2008-2012.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Hall HI et al. MMWR Morb. Mortal. Wkly. Rep.2015 Jun 26. (24) 657-62
Hall HI et al. MMWR Morb. Mortal. Wkly. Rep.2015 Jun 26. (24) 657-62
Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999-2011.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Buchacz K et al. J. Antimicrob. Chemother. 2015 May 15.
Buchacz K et al. J. Antimicrob. Chemother. 2015 May 15.
A global health diagnostic for personalized medicine in resource-constrained world settings: A simple PCR-RFLP method for genotyping CYP2B6 g.15582C>T and science and policy relevance for optimal use of antiretroviral drug Efavirenz![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Jonathan E et al, J Integrative Biology, June 2015
Jonathan E et al, J Integrative Biology, June 2015
Detection of acute HIV-1 infection by RT-LAMP.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Rudolph DL et al. PLoS ONE 2015 (5) e0126609
Rudolph DL et al. PLoS ONE 2015 (5) e0126609
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Joseph SB et al, Nature Reviews Microbiology, June 8, 2015
Joseph SB et al, Nature Reviews Microbiology, June 8, 2015
The impact of host genetic variation on infection with HIV-1.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
McLaren PJ et al. Nat. Immunol. 2015 May 19. (6) 577-583
McLaren PJ et al. Nat. Immunol. 2015 May 19. (6) 577-583
Genome-wide association studies of HIV-1 host control in ethnically diverse Chinese populations.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Wei Z et al. Sci Rep 2015 10879
Wei Z et al. Sci Rep 2015 10879
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: An individual-patient- and sequence-level meta-analysis![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Soo-Yon R et al. PLOS Medicine, April 2015
Soo-Yon R et al. PLOS Medicine, April 2015
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Liao HK et al. Nat Commun 2015 6413
Liao HK et al. Nat Commun 2015 6413
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Zhu W et al. Retrovirology 2015 (1) 22
Zhu W et al. Retrovirology 2015 (1) 22
An integrated map of HIV genome-wide variation from a population perspective.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Li G et al. Retrovirology 2015 (1) 18
Li G et al. Retrovirology 2015 (1) 18
Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: A genome-wide association study.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Johnson EO et al. PLoS ONE 2015 (3) e0118149
Johnson EO et al. PLoS ONE 2015 (3) e0118149
HIV latency and the noncoding RNA therapeutic landscape.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Saayman S et al. Adv. Exp. Med. Biol. 2015 169-89
Saayman S et al. Adv. Exp. Med. Biol. 2015 169-89
Editing CCR5: A novel approach to HIV gene therapy.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Cornu TI et al. Adv. Exp. Med. Biol. 2015 117-30
Cornu TI et al. Adv. Exp. Med. Biol. 2015 117-30
Gene therapy strategies to block HIV-1 replication by RNA interference.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Herrera-Carrillo E et al. Adv. Exp. Med. Biol. 2015 71-95
Herrera-Carrillo E et al. Adv. Exp. Med. Biol. 2015 71-95
Possible biomarkers for the early detection of HIV-associated heart diseases: A proteomics and bioinformatics prediction.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Rasheed S et al. Comput Struct Biotechnol J 2015 145-52
Rasheed S et al. Comput Struct Biotechnol J 2015 145-52
Targeting the HIV RNA genome: High-hanging fruit only needs a longer ladder.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Le Grice SF J et al. Curr. Top. Microbiol. Immunol. 2015 Mar 4.
Le Grice SF J et al. Curr. Top. Microbiol. Immunol. 2015 Mar 4.
Genome editing strategies: potential tools for eradicating HIV-1/AIDS.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Khalili K et al. J. Neurovirol. 2015 Feb 26.
Khalili K et al. J. Neurovirol. 2015 Feb 26.
The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Herrera-Carrillo E et al. Gene Ther. 2015 Feb 26.
Herrera-Carrillo E et al. Gene Ther. 2015 Feb 26.
The interplay between host genetic variation, viral replication, and microbial translocation in untreated HIV-infected individuals.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Perkins MR et al. J. Infect. Dis. 2015 Feb 20.
Perkins MR et al. J. Infect. Dis. 2015 Feb 20.
Data-intensive analysis of HIV mutations.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Ozahata M et al. BMC Bioinformatics 2015 Feb 5. (1) 35
Ozahata M et al. BMC Bioinformatics 2015 Feb 5. (1) 35
HIV-1 adaptation to HLA: a window into virus-host immune interactions.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Carlson JM et al. Trends Microbiol. 2015 Jan 19.
Carlson JM et al. Trends Microbiol. 2015 Jan 19.
Genomics of HIV infection.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Telenti A et al. Curr Opin HIV AIDS 2015 Mar (2) 77-8
Telenti A et al. Curr Opin HIV AIDS 2015 Mar (2) 77-8
Application of gene-editing technologies to HIV-1.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Drake MJ et al. Curr Opin HIV AIDS 2015 Mar (2) 123-7
Drake MJ et al. Curr Opin HIV AIDS 2015 Mar (2) 123-7
Genome editing-based HIV therapies.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Gu WG et al. Trends Biotechnol. 2015 Mar (3) 172-179
Gu WG et al. Trends Biotechnol. 2015 Mar (3) 172-179
HIV/AIDS: Recent Genomic Insights - December 4, 2014
CDC Vital Signs: HIV care saves lives. Viral suppression is key, November 2014
Recent Advances
Review: influence of ART on HIV genetics.
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Hu W, et al. PNAS, Jul 21, 2014.
Hu W, et al. PNAS, Jul 21, 2014.
Genome editing cuts out HIV![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Grens K. The Scientist, Jul 21, 2014.
Grens K. The Scientist, Jul 21, 2014.
Gene researchers work to engineer HIV-resistant cells
Hampton T. JAMA, Jul 9, 2014.
Hampton T. JAMA, Jul 9, 2014.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Promising results from HIV gene editing therapy,
PHG Foundation, Mar 10
Testing for risk and protective trends in genetic analyses of HIV acquisition.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Mccarthy JM, et al. Biostatistics. 2014 Sep 29
Mccarthy JM, et al. Biostatistics. 2014 Sep 29
Biomarkers of HIV-associated Cancer.![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi
HIV/AIDS Genomics: Advances in Therapy and Tests - July 31, 2014
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Hu W, et al. PNAS, Jul 21, 2014.
Hu W, et al. PNAS, Jul 21, 2014.
Genome editing cuts out HIV![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Grens K. The Scientist, Jul 21, 2014.
Grens K. The Scientist, Jul 21, 2014.
Gene researchers work to engineer HIV-resistant cells
Hampton T. JAMA, Jul 9, 2014.
Hampton T. JAMA, Jul 9, 2014.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Promising results from HIV gene editing therapy,
PHG Foundation, Mar 10
Check out guidelines on genomic tests associated with HIV/AIDS treatment, from the CDC evidence-based table
HLA-B*5701/abacavir | |
CCR5-tropic HIV-1 /maraviroc |
Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.
Did you know? 1799 genes have been reported in relation to HIV risk & outcomes including 33 genomewide association studies. To find out more, visit the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3-testonly.googleusercontent.com/blogger_img_proxy/AEn0k_sxXumhA0XhqAQe-hpLoK75Gyq9-v-u71VvR2bJtPKvm5vpwZxiV8uusAW0r1K_c9XSTb6xnvITXkH9t7QIGC8PmczeMr6n8f0sHMejQSA3xtjWv6z8XY8r=s0-d)
No hay comentarios:
Publicar un comentario