Statins UPDATE || Public Health Genomics Knowledge Base (v1.0) || July 7-14, 2016

Public Health Genomics Knowledge Base (v1.0)



July 7-14, 2016 


Last Updated: Jul 07, 2016

• Marginal role for 53 common genetic variants in cardiovascular disease prediction.
  Morris Richard W, et al. Heart (British Cardiac Society) 2016 6
• The frequency of SLCO1B1*5 polymorphism genotypes among Russian and Sakha (Yakutia) patients with hypercholesterolemia.
  Sychev Dmitrij Alekseevitch, et al. Pharmacogenomics and personalized medicine 2016 0 59-63
• Phase I biomarker modulation study of atorvastatin in women at increased risk for breast cancer.
  Arun Banu K, et al. Breast cancer research and treatment 2016 6
• My Approach to the Patient With Familial Hypercholesterolemia.
  Safarova Maya S et al. Mayo Clinic proceedings 2016 Jun 91(6) 770-86
• Identifying familial hypercholesterolemia in acute coronary syndrome.
  Gencer Baris et al. Current opinion in lipidology 2016 Apr
• Prevalence of heterozygous familial hypercholesterolaemia and its impact on long-term prognosis in patients with very early ST-segment elevation myocardial infarction in the era of statins.
  Rallidis Loukianos S et al. Atherosclerosis 2016 Mar 24917-21
• Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia.
  Besseling Joost et al. European heart journal 2016 Apr
• Phenotype diversity among patients with homozygous familial hypercholesterolemia: A cohort study.
  Raal Frederick J, et al. Atherosclerosis 2016 3
• Genetic insights into statin-associated diabetes risk.
  Swerdlow Daniel I, et al. Current opinion in lipidology 2016 4 (2) 125-30
• The UK Paediatric Familial Hypercholesterolaemia Register: preliminary data.
  Ramaswami Uma et al. Archives of disease in childhood 2016 Mar
• The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy.
  Feng Q, et al. The pharmacogenomics journal 2016 2
• Seventeen years of statin pharmacogenetics: a systematic review.
  Leusink Maarten et al. Pharmacogenomics 2016 Jan (2) 163-80
• Statin-Associated Autoimmune Myopathy
  AL Mammen. NEJM, February 18, 2016
• Improving the cost-effectiveness equation of cascade testing for familial hypercholesterolaemia.
  Pears Robert et al. Current opinion in lipidology 2015 Jun 26(3) 162-8
• Management of Familial Hypercholesterolemia in Hong Kong.
  Hu Miao et al. Journal of atherosclerosis and thrombosis 2016 Feb

• Human (15)
• Pathogen (0)

• Human (373)
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• Human (18)
• Pathogen (0)

• Guidelines (5)
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• Synthesis (11)

Relevant Resources

• Cancer Genomics and Epidemiology Navigator (CGEN)
• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB